Growth hormone receptor blockers is used to treat acromegaly and works by blocking the sites on cells where growth human growth hormones dock. When the excess growth hormone in the blood is unable to dock on the cells, the abnormal cell growth is blocked.
Recommended Resources
Dose-response Effects of New Growth Hormone Receptor Antagonist
From the Journal of Endocrinology, this review lays out the role of growth hormone in regulating renal growth hormone and insulin-like growth factor and the effects of growth hormone receptor antagonists on regulating them.
http://joe.endocrinology-journals.org/cgi/content/abstract/167/2/295
Growth Hormone Receptor Antagonists and Use in Patients with Acromegaly
Scholarly review dissects the use of growth hormone receptor blockers in patients with acromegaly, the discovery and development of the antagonists, and outside citations.
http://edrv.endojournals.org/content/23/5/623.abstract
Treatment of Acromegaly with the Growth Hormone–Receptor Antagonist
Consists of a paper about Pegvisomant in the treatment of acromegaly, a syndrome in which the pituitary gland over produces growth hormone.
http://www.nejm.org/doi/full/10.1056/NEJM200004203421604
