Norepinephrine-dopamine reuptake inhibitors act as a reuptake inhibitor specifically for the neurotransmitters dopamine and norepinephrine. They block the action of the transporters which leads to more extracellular concentrations of dopamine and norepinephrine which in turn leads to an increase in adrenergic and dopaminergic transmission.
Recommended Resources
The NDRI Amoryn, which has as its main ingredient hyperforin, is the subject of this site, which is maintained by the manufacturer. It dispenses data about the ingredients, scientific research, and safety facts.
http://www.amoryn.com/
Norepinephrine and Dopamine Reuptake Inhibitors (NDRIs)
Passes on information about NDRIs, how they work and what the common side effects are.
http://www.anti-depressants.us/ndris.php
Review of the Neuropharmacology of Bupropion, a Dual Norepinephrine and Dopamine Reuptake Inhibitor
Delves into details about the neurochemical and biological effects of antidepressants in this study which finds that bupropion acst via the dual inhibition of NDRIs and has demonstrated efficacy which is similar to otther antidepressants.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC514842/
