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The Mississippi Rover port city of Natchez, the county seat of Adams County, Mississippi, was founded in 1716 by French colonists. It was the site of the so-called Natchez Massacre in 1729, in which the Natchez Indians killed 229 of the colonists. Over the next two years, counterattacks by the French and some of their Indian allies resulted in the death, enslavement, or departure of all of the Natchez Indians.

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