A mitotic inhibitor is a kind of drug which is a derivative of natural substances, for example, plant alkaloids. They are used in cytogenetics and in cancer as cancer cells metastasize by continuous mitotic division. Mitotic inhibitors interfere with mitosis, disabling the cells from dividing.
Recommended Resources
Journal of Thoracic Oncology: Mitotic Inhibitors
Lengthy, in-depth article provides details of these inhibitors including a description of the mechanisms of resistance to taxanes and the potential of the epothilones and a link to the PDF version of the article.
http://journals.lww.com/jto/Fulltext/2009/11001/Mitotic_Inhibitors.11.aspx
Studies on the Antimitotic Activity of Leurocristine
Overview of vincristine presents the agent's effects on cell division in bone marrow and leukemic cells.
http://bloodjournal.hematologylibrary.org/content/21/1/102.abstract
Furnishes facts regarding vinblastine, trade name Velban, and its effects on Hodgkin's disease, breast cancer, and lymphomas as well as possible side effects.
http://www.tirgan.com/velban.htm
