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The city of Macon, Missouri is the county seat of Macon County. The area that was to become Macon began to be settled in the early 1820s, largely consisting of people from Kentucky, North Carolina and Tennessee, who were following an old Indian trade route known as the Great Trail. The town was laid out in 1856, and named for Nathaniel Macon, a North Carolina senator and representative, as had the county. The town’s population grew quickly, in large part because of two railroad lines, the Northwest Railroad and the Hannibal and St. Joseph Railroad, which intersected in Macon. During the American Civil War, about seven thousand Union troops were stationed in Macon, and the county seat was moved from Bloomington to Macon in 1863, largely because it was a Union troop concentration while Bloomington was pro-Confederate. Today, US Highways 36 and 63 intersect in Macon. Long Branch State Park is northwest of the city, as is the city of Bloomington. Anabel is east of Macon, Axtell is to the north, and Excello is to the south.

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