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Situated at the intersection of Interstate Highway 70, which is also US Highway 40, and Missouri Highway 19, in Montgomery County, Missouri, the small city of New Florence is about one hour west of St. Louis, an hour east of Columbia, and twenty minutes north of Hermann. Nearby communities include Danville to the west, High Hill to the east, Montgomery City to the north, and Bigspring to the south. Settled in the mid-19th century, the New Florence post office was established in 1858.



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